Principal Scientist I/II, Oligonucleotide Chemistry & Innovation

Overview

In this role you will advance Novartis’ xRNA platform by leading oligonucleotide chemistry development and cross-functional collaboration to drive RNA therapeutics from discovery through preclinical stages. You’ll mentor scientists, optimize synthetic routes, and implement robust workflows to accelerate innovation in a fast-paced research environment. This position offers the chance to shape the next generation of RNA medicines and make a meaningful impact on patients worldwide. You will work with a world-class team to transform therapeutic concepts into tangible solutions.

Pay / Benefits

• flexible and hybrid working options
• 14 weeks paid parental leave
• insurance plans
• retirement plans
• wellbeing resources
• global recognition programs

Responsibilities

• Lead synthesis, purification, characterization, and analysis of chemically modified oligonucleotides and conjugates
• Design and optimize novel oligonucleotide chemistries through structure-activity relationship studies
• Develop and implement robust synthetic routes for preclinical RNA therapeutic candidates
• Drive cross-functional collaboration to advance oligonucleotide therapeutic programs from discovery through preclinical stages
• Mentor scientists and enhance laboratory workflows to improve efficiency, quality, and innovation
• Establish and maintain SOPs supporting reproducible oligonucleotide manufacturing processes
• Operate, troubleshoot, and maintain analytical and synthesis instrumentation including HPLC and LC-MS

Key requirements

• PhD in Chemistry or related field
• At least five years of experience synthesizing therapeutic oligonucleotides in industry or research
• Deep expertise in solid-phase oligonucleotide synthesis, deprotection, purification, and characterization
• Proven experience developing and optimizing novel oligonucleotide chemistries and conjugates
• Strong knowledge of phosphoramidite chemistry and modern synthetic techniques
• Hands-on experience with automated oligonucleotide synthesizers and analytical instrumentation
• Understanding of RNA therapeutics including siRNA and antisense oligonucleotides
• Excellent collaboration and communication skills across multidisciplinary teams

• collaboration
• communication
• mentorship
• solid-phase oligonucleotide synthesis
• deprotection
• purification and characterization of oligos

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