Process Engineer, Drug Substance Development

Overview

As a Process Engineer in GSK’s Drug Substance Development team, you apply engineering to develop scalable, robust pharmaceutical manufacturing processes using digital tools and data analytics. You will work in R&D labs with chemists to build process understanding for scale-up and commercialisation, transferring knowledge to pilot and manufacturing facilities. You’ll combine digital data, process modelling and engineering principles to de-risk scale-up and support technology transfer, with opportunities across small molecules, oligonucleotides and potentially large molecules. You will operate in a compliant, safety-conscious, data-driven environment.

Pay / Benefits

• agile working culture
• potential relocation to Ware (timelines to be set)

Responsibilities

• Design and execute scale-up and scale-down experiments across unit operations to build process understanding within tight timelines
• Think creatively to optimise engineering solutions and de-risk scale-up processes
• Analyse experimental results and present conclusions and recommendations to internal R&D
• Contribute to technology-transfer activities with GSK manufacturing partners, providing engineering input aligned with project stage
• Leverage digital data and analytics alongside engineering expertise to inform process-development decisions and manage scale-up risk
• Author or contribute to internal documentation relevant to the role
• Ensure compliance with Data Integrity, Quality, cGMP and regulatory requirements and uphold lab safety

Key requirements

• BSc/BEng/Masters / PhD (or equivalent) in Process/Chemical Engineering
• Experience in a pharmaceutical plant and/or direct laboratory experience in the pharmaceutical industry, or related sector

• Cross-functional collaboration
• Problem solving
• Clear communication of results and recommendations
• Process simulation/modelling (e.g., DynoChem)
• Experience with digital process data collection and analytics (including PAT)
• Understanding of GxP, data integrity and regulatory compliance

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