Research Scientist I/II: Pharmacology

Overview

In this role, you will drive in vivo efficacy and PK/PD studies to evaluate novel cancer therapies. You will build and use CDX, PDX and syngeneic models within a multidisciplinary oncology pharmacology team to support early drug discovery. You will analyze data, communicate findings, and ensure rigorous documentation and adherence to animal protocols. This position offers a meaningful chance to impact preclinical decisions in a leading oncology portfolio.

Pay / Benefits

• performance-based cash incentive
• eligibility for annual equity awards
• comprehensive health, life and disability benefits
• 401(k) with company contribution and match
• generous time off package
• reasonable accommodations

Responsibilities

• Execute pre-clinical in vivo studies to test hypotheses and screen compounds
• Develop and utilize CDX, PDX, and syngeneic tumor models to assess anti-tumor activity, PK/PD, and biomarkers
• Collaborate with pharmacology team to design and run studies independently
• Analyze and present results within a multidisciplinary team
• Maintain strict adherence to animal protocols and document data/methods in electronic notebooks

Key requirements

• BS/MS in biological sciences with 2+ years (Sci I) or 4+ years (Sci II) in pharmaceutical/biotech industry
• Extensive experience with CDX/PDX xenograft and/or syngeneic models
• Experience with cell culture
• Hands-on mouse/rat handling and dosing (IV, IP, PO), tumor implantation, caliper measurements, imaging, and tissue collection
• Experience with PCR, ELISA, western blot, and flow cytometry
• Strong analytical, written and verbal communication skills; proficient in PowerPoint and data analysis tools (Excel, Prism)

• Highly motivated
• Inquisitive and creative
• Thrives in a matrixed, cross-functional environment
• In vivo tumor models: CDX, PDX, syngeneic
• Cell culture
• Mouse/rat handling and dosing (IV, IP, PO)

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