Associate/Research Scientist – Upstream Process Sciences

Job Description

A successful pharmaceutical company is looking for an Associate Scientist / Research Scientist to join its Drug Substance Process Sciences team and support the development of innovative biologics.

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This is a hands-on laboratory role focused on upstream process development, optimisation and characterisation, with exposure to mammalian cell culture, high-throughput platforms and bioreactor systems from microscale through to pilot scale.

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Key Responsibilities

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• Design and execute upstream process development studies.

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• Develop and optimise mammalian/CHO cell culture processes.

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• Operate shake flasks, Ambr® systems and laboratory-scale bioreactors.

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• Apply DoE and QbD approaches to process optimisation and characterisation.

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• Support scale-up, troubleshooting, technology transfer and manufacturing activities.

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• Analyse experimental data and communicate findings through reports and presentations.

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• Collaborate with Cell Line Development, Analytical Sciences, Downstream Development and Manufacturing teams.

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• Maintain high standards of GMP, data integrity, HSE and laboratory compliance.

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About You

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Essential:

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• BSc or MSc in Biotechnology, Biochemical Engineering, Chemical Engineering, Molecular Biology, Cell Biology, Bioprocess Engineering or a related discipline

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• Hands-on experience with mammalian/CHO cell culture and biologics process development

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• Experience with Ambr® and/or laboratory-scale bioreactors

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• Understanding of cell culture scale-up and process characterisation

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• Experience with DoE and statistical data analysis

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• Strong scientific problem-solving and troubleshooting skills

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Desirable:

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• Perfusion or ATF experience

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• Technology transfer or manufacturing support experience

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• Exposure to downstream processing or integrated process development

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This role is offered on an initial 12 month contract with realistic potential for extension.

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Why Apply?

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An excellent opportunity to develop your career within upstream bioprocess development, gaining hands-on experience across cell culture, bioreactor systems, process optimisation, scale-up and technology transfer within a successful pharmaceutical environment.

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Keywords: Upstream Process Development | Bioprocessing | Mammalian Cell Culture | CHO | Bioreactors | Ambr | Process Characterisation | Scale-Up | DoE | QbD | Perfusion | ATF | Biologics | Therapeutic Proteins | GMP | Pharmaceutical | Biopharmaceutical

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