Principal Scientist – Cardiac Electrophysiology & Translational Ion Channels

Overview

In this role you will shape and lead the cardiac electrophysiology and translational ion channel strategy across multiple drug discovery programs. You will bridge bench science with client-driven decision making, translating electrophysiology data into strategic programme directions. You will oversee laboratory science while guiding cross-functional teams and mentoring scientists to advance translational cardiac safety. This is a hands-on leadership role that combines strategic vision with active bench involvement to push translational cardiovascular science forward.

Pay / Benefits

• corporate benefits package
• bonus
• opportunities for leadership development

Responsibilities

• Set and execute the scientific strategy for cardiac electrophysiology and translational ion channel research across multiple programmes
• Lead multidisciplinary project teams and act as primary scientific contact for clients
• Interpret integrated in vitro, ex vivo, and translational data to guide project progression
• Drive innovations in cardiac safety and translational biology; adopt new technologies as appropriate
• Oversee electrophysiology platforms (Qube, MEA) and guidance on experimental design and data interpretation
• Lead studies using hIPSC-derived cardiomyocytes and translational cardiac models
• Ensure high-quality data generation aligned with client/programme objectives
• Mentor and develop scientists; contribute to recruitment and talent development

Key requirements

• PhD with significant industrial drug discovery experience
• Expertise in cardiac electrophysiology, cardiac safety pharmacology, translational cardiovascular biology, and ion channel pharmacology
• Proven leadership of multidisciplinary scientific teams and programmes
• Strong client-facing and stakeholder management capabilities
• Hands-on experience with automated patch clamp platforms (Qube preferred), MEA technologies, hIPSC-derived cardiomyocytes, and translational cardiac models
• Experience translating complex scientific data into strategic programme recommendations

• client-facing communication
• stakeholder management
• mentoring and people leadership
• Automated patch clamp platforms (Qube/Sophion)
• MEA technologies
• hIPSC-derived cardiomyocytes

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