In Vivo Research Scientist

Overview

As a Research Scientist you will design and execute in vivo gene therapy studies to support preclinical and early clinical development. You’ll work across ocular/retinal and CNS models, driving the development and evaluation of AAV-based therapies. You will collaborate with R&D, quality, and regulatory functions to deliver high-quality preclinical data and contribute to study protocols and investigations. This role offers a hands-on, impact-focused opportunity to shape gene therapy programmes in a growing team.

Responsibilities

• Design, establish and execute in vivo gene therapy studies in mice
• Take studies from initial set-up through to execution, data interpretation and reporting
• Develop and optimise in vivo potency and safety assays supporting gene therapy programmes
• Work with ocular/retinal, brain or CNS models, particularly technically challenging or specialised procedures
• Support the development and evaluation of AAV-based gene therapies and associated therapeutic readouts
• Troubleshoot studies and develop new approaches, techniques and experimental workflows
• Analyse and interpret preclinical data to support programme progression towards the clinic
• Produce high-quality study reports, SOPs, experimental protocols and work instructions
• Contribute to the establishment and implementation of new in vivo models, assays and laboratory processes
• Work collaboratively across R&D, quality, regulatory and compliance functions
• Support programmes across both preclinical research and early clinical development

Key requirements

• Strong, hands-on in vivo experience using mice
• Current or previous Home Office Personal Licence (PIL A/C)
• Experience performing technically challenging or specialised in vivo procedures
• Proven experience within gene therapy, ideally AAV-based gene therapy
• Strong preclinical research experience
• Experience setting up, establishing or taking ownership of new in vivo studies
• Experience writing study reports, SOPs, protocols and scientific documentation
• Strong experimental design, data interpretation and troubleshooting skills
• Ocular/retinal in vivo experience, alternatively, strong brain/CNS/neuroscience experience

• collaboration across functions
• analytical thinking
• troubleshooting
• in vivo mouse studies
• AAV-based gene therapy
• ocular/retinal in vivo procedures

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