Are you looking to make an impact with your innovation? We are working with a well-established pharmaceutical company to recruit for a driven scientist!
Proclinical is working alongside a leading global pharmaceutical organisation is seeking an experienced Materials Characterisation & Formulation Scientist to support drug product development, material change assessments, and manufacturing process performance prediction activities.This is an excellent opportunity for a pharmaceutical scientist with expertise in oral solid dosage forms (OSD), formulation development, process development, manufacturing science, material characterisation, and pharmaceutical manufacturing operations.You will play a key role in understanding how raw material, excipient, and API variability can impact product quality, manufacturability, and process robustness, using a combination of laboratory experimentation, process understanding, and scientific data analysis.
Key Responsibilities
- Design and execute formulation and process development studies.
- Evaluate the impact of API and excipient variability on manufacturing performance and product quality.
- Assess supplier changes and material variability through laboratory experimentation and risk assessment activities.
- Develop representative small-scale models of pharmaceutical manufacturing processes.
- Investigate relationships between material attributes, process parameters, and critical quality attributes (CQAs).
- Conduct studies involving:
- Powder blending
- Content uniformity
- Wet granulation
- Dry granulation
- Powder flow and feeding behaviour
- Tablet compression
- Compaction analysis
- Tablet sticking investigations
- Film coating
- Stability and robustness assessments
- Support process understanding, scale-up activities, and manufacturability assessments.
- Analyse experimental data and provide scientific recommendations.
- Prepare technical reports, presentations, and project updates.
- Collaborate with multidisciplinary teams including formulation, process, analytical, and manufacturing scientists.
Skills & Experience Required
- Degree in Pharmaceutical Sciences, Pharmaceutics, Chemistry, Chemical Engineering, Materials Science, or a related discipline.
- Proven years’ experience within pharmaceutical development, pharmaceutical manufacturing, MSAT, process development, or formulation development environments.
- Strong knowledge of oral solid dosage forms (OSD) including tablets and capsules.
- Experience with pharmaceutical manufacturing unit operations including:
- Blending
- Granulation
- Compression
- Film coating
- Understanding of material attributes and their impact on product and process performance.
- Experience designing experimental studies and interpreting scientific data.
- Knowledge of process robustness, scale-up principles, and manufacturing performance assessment.
- Strong technical writing and scientific reporting experience.
- Excellent problem-solving and stakeholder communication skills.
Highly Desirable
- Experience supporting technology transfer, scale-up, or commercial manufacturing.
- Knowledge of statistical analysis, Design of Experiments (DoE), process modelling, simulation tools, or predictive modelling.
- Experience investigating manufacturing challenges and process performance issues.
- Familiarity with material characterisation techniques and risk-based decision making.
What’s on Offer?
- Opportunity to join a highly respected global pharmaceutical organisation.
- Complex and scientifically challenging development projects.
- Exposure to commercial manufacturing and product lifecycle activities.
- Collaborative multidisciplinary environment.
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