Principal Statistician – Early Phase – Fully home based (remote anywhere in Europe) Sponsor Dedicated

Overview

In this fully remote Europe-based role, you drive statistical leadership for early-phase clinical trials within Syneos Health. You mentor biostatisticians, oversee project delivery, and shape statistical strategy from protocol to CSR. You collaborate with sponsors and cross-functional teams to ensure high-quality analyses and regulatory-ready documentation. You’ll lead complex analyses, contribute to submissions, and support business development while upholding our patient-centric, results-driven culture.

Pay / Benefits

• career development and progression
• supportive line management
• technical/therapeutic area training
• peer recognition
• total rewards program

Responsibilities

• Mentor and train biostatistics personnel; oversee project work and ensure timely, high-quality output
• Direct statistical activities on assigned projects; review work of colleagues for independence and quality
• Provide cross-lifecycle statistical support from protocol through CSR; collaborate with sponsors as needed
• Prepare or oversee SAP development and create presentation-ready tables, listings, and figures
• Lead statistical aspects of protocols, randomization plans, and input to CSR as needed
• Review programming specifications for analysis datasets, TLFs, and figures; assess CRF/database documentation for data integrity
• Manage project timelines and milestones across multiple studies; escalate out-of-scope tasks and adjust schedules
• Participate in DSMB/DMC activities as independent statistician or voting member; ensure regulatory guideline compliance
• Support regulatory submissions and client proposals; contribute to bid defense meetings
• Maintain comprehensive, inspection-ready project documentation and adherence to SOPs/WIs
• Contribute to internal meetings, share ideas, and collaborate with cross-functional teams
• Provide statistical programming support and engage in data safety monitoring oversight as applicable
• Occasionally travel as required

Key requirements

• Graduate degree in biostatistics or related discipline
• Extensive experience in clinical trials and ability to lead multiple programs
• Proficiency in R programming
• Strong knowledge of statistical design, analysis, regulatory guidelines, and programming techniques
• Experience across all statistics tasks from protocol to CSR; regulatory submissions preferred
• Excellent written and verbal communication skills; English proficiency
• Ability to read/write/speak English
• Experience with SAS is advantageous
• PhD or MSc in statistics or related discipline (preferred per summary)
• Strong decision-making and timeline management skills

• Leadership and mentorship
• Strong communication and collaboration
• Attention to detail and quality focus
• R programming
• SAS
• Statistical design and analysis

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