Research Associate in Alzheimer’s Disease Mechanisms (Tau Biology)

Overview

Research Associate role focused on unraveling early tau aggregation and seeding linked to neurodegeneration, within an ARUK-funded project across Imperial College London and the University of Oxford. You will apply integrated cell-based and biochemical methods to identify seeding-competent tau species and understand astrocyte and amyloid-beta influences. The position offers cross-institution collaboration, skill development, and opportunities to publish and contribute to funding applications.

Pay / Benefits

• ARUK-funded programme
• Collaborative environment across Imperial and Oxford
• Access to advanced facilities in neuropathology, biochemistry, and imaging
• Opportunities to publish and develop independence
• Career development support including 10 development days per year
• Competitive salary, pension, and benefits package

Responsibilities

• Design and perform experiments on early tau aggregation and seeding
• Work with mammalian cell culture to study protein uptake and propagation
• Apply biochemical methods to characterize aggregation states and protein species
• Use molecular approaches to modulate gene or protein expression in cellular systems
• Integrate cell-based and biochemical techniques in multi-step workflows
• Analyze data, interpret results, and refine research strategies
• Collaborate with teams at Imperial and Oxford
• Coordinate project activities and supervise a PhD student

Key requirements

• PhD (or near completion) in a relevant discipline
• Demonstrated experience in mammalian cell culture
• Strong experience in protein-focused experimental work and biochemical characterization of protein states
• Experience with molecular manipulation of cellular systems (e.g., transfection, gene expression modulation)
• Experience working across multi-step experimental workflows
• Proven ability to design, execute, and troubleshoot experiments independently
• Evidence of research output (publications or equivalent)

• Collaborative mindset
• Independent problem-solving
• Strong troubleshooting ability
• Mammalian cell culture
• Protein biochemistry and characterization of protein states
• Transfection and gene expression modulation

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