Senior Clinical Research Physician

Overview

In this role you will provide medical leadership for the Clinical Unit Cambridge, serving as Principal Investigator on early-phase and experimental medicine studies to deliver high-quality, safe trials. You will integrate clinical and scientific expertise with central GSK teams to shape design, conduct, and interpretation of FIH and mechanistic studies. You will lead medical safety governance, drive protocol development, and ensure regulatory compliance while fostering a collaborative, innovative research culture.

Responsibilities

• Act as co-PI or PI on clinical pharmacology, experimental medicine, and FTIH studies, aligned with accreditation requirements
• Provide medical authority on protocol development, risk–benefit assessment, and data interpretation for unit studies
• Author and approve informed consent documents and REC/submission materials, responding to regulatory questions
• Lead protocol-related activities including recruitment support, informed consent, screening, monitoring, and data interpretation
• Oversee diagnostic/therapeutic procedures and assist with processing
• Provide flexible clinical support and supervision of procedures conducted by nursing staff and Physician Associates
• Oversee dosing of IMPs and non-IMPs via multiple routes ensuring safety and accuracy
• Provide medical cover for recruitment, conduct, follow-up, including out-of-hours on-call when required
• Drive methodological innovation in trials (adaptive designs, PK/PD, digital endpoints, imaging)
• Ensure medical safety and governance decisions, manage adverse events, and maintain high-quality documentation

Key requirements

• Medical degree with full GMC registration and licence
• UK-trained doctors with early Speciality or GP training and acute medicine experience; or non-UK with GMC registration
• Experience in early clinical development/experimental medicine with PI or sub-investigator roles and MHRA accreditation alignment
• Experience in clinical pharmacology in early phase I/II studies
• Experience with biomarker strategy, PK/PD, and mechanism-of-action driven development
• Experience leading study teams focused on quality, timeliness, and budget
• Experience working with central teams on FTIH and translational medicine projects

• strong communication and presentation skills
• leadership and people management
• cross-functional collaboration
• Clinical Development
• Good Clinical Practice (GCP)
• Pharmacology and PK/PD

…