Senior Principal Scientist, Translational Profiling Imaging

Overview

In this role you lead a translational profiling group focused on advanced imaging and spatial biology to enable target discovery and validation across disease areas. You shape imaging capabilities and integrate multi-omics and molecular profiling to answer key biological questions. You work with cross-functional teams to accelerate translation from target identification to mechanism of action studies. This position combines hands-on experimentation with strategic leadership to drive innovation in translational biology.

Pay / Benefits

• performance-based incentive
• equity eligibility
• health, life and disability benefits
• 401(k) with company match
• generous time off package
• career development opportunities

Responsibilities

• Lead development and application of translational biology, imaging, and profiling strategies across the drug discovery pipeline
• Design and implement novel assays and integrated workflows using imaging, spatial biology, proteomics, and related technologies
• Maintain hands-on scientific presence through experimental design, assay development, troubleshooting, and data interpretation
• Generate biological insights on disease mechanisms, pharmacology, target biology, tissue and cell targeting, and translational biomarkers
• Lead cross-functional matrix teams and collaborate with project teams, platform scientists, and disease-area researchers
• Shape strategy and evolution of imaging, spatial biology, and translational profiling capabilities, identifying opportunities for innovation
• Establish and manage external collaborations to evaluate emerging technologies
• Mentor and develop scientists to foster excellence and collaboration
• Communicate findings and strategic recommendations to project teams and senior stakeholders

Key requirements

• Ph.D. in Biology, Cell and Molecular Biology, or a related life sciences discipline with 7+ years in drug discovery
• Strong hands-on experience in cellular and tissue-based models and advanced microscopy (confocal, super-resolution)
• Proven track record applying imaging and translational biology to understand disease and therapeutic mechanisms across diseases
• Demonstrated scientific leadership, mentoring, and cross-functional collaboration in a matrix environment
• Passion for innovation and emerging technologies, including AI-enabled imaging, omics, and multidimensional data analysis
• Excellent collaboration, communication, and problem-solving skills with a track record of scientific impact

• collaboration
• communication
• problem-solving
• advanced imaging (confocal, super-resolution)
• spatial biology
• proteomics

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