Principal Scientist II, Translational Biomarker Strategy Lead

Overview

In this role you will lead and shape preclinical and translational biomarker strategies for DAx programs, guiding target validation to early clinical planning. You will act as the biomarker representative on project teams, coordinating across biology, in vitro/in vivo science, data science, and biomarker development to inform program milestones. You will drive external collaborations and deliver execution-ready biomarker plans that support target engagement and patient stratification, enabling efficient progression of the portfolio. This is a unique opportunity to accelerate translational decisions at Novartis by integrating scientific, technical, and operational expertise.

Pay / Benefits

• flexible and hybrid working options
• 14 weeks paid parental leave
• insurance plans
• retirement plans
• wellbeing resources
• global recognition programs

Responsibilities

• Lead stage-appropriate preclinical and translational biomarker strategies from validation through early development readiness.
• Serve as the biomarker representative and single point of contact on DAx project teams.
• Define hypotheses, context of use, evidence requirements, and decision criteria aligned with milestones.
• Develop integrated biomarker plans covering assays, models, samples, analyses, timelines, and external partnerships.
• Coordinate across Biology, In Vitro, In Vivo, Data Science, Preclinical Safety, Quantitative Sciences, Translational Medicine, and Biomarker Development to align activities.
• Generate translational evidence linking target biology, pharmacology, and biomarkers to support portfolio decisions.
• Drive external collaborations and leverage innovative technologies, datasets, and human samples to strengthen strategies and transitions.

Key requirements

• PhD, MD, PharmD, or equivalent in bioscience or related field
• 7+ years in translational research, biomarker strategy, biomarker discovery, or drug development in pharma/biotech
• Experience developing biomarker strategies supporting drug discovery and development
• Strong understanding of biomarker applications including target engagement, pharmacodynamics, patient stratification, disease activity, and mechanism-based biomarkers
• Experience leading cross-functional matrix teams and influencing scientific strategy without direct authority
• Excellent communication, presentation, and stakeholder management skills

• Excellent communication
• Stakeholder management
• Cross-functional collaboration
• Biomarker strategy development
• Target engagement and pharmacodynamics
• Translational medicine and biomarker development

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