Principal Scientist – Protein Mass Spectrometry

Overview

In this role you apply protein mass spectrometry expertise to characterise biotherapeutics, guiding early-phase development and critical decisions on quality attributes. You’ll work across Discovery and CMC Development in a matrix environment, translating analytical findings into actionable insights for project advancement. The position blends lab-based work with cross-functional collaboration to support tech transfers, degradation studies and regulatory documentation. This role offers exposure to diverse modalities and analytical technologies, with a clear impact on turning promising molecules into medicines.

Pay / Benefits

• hybrid working model
• competitive salary
• annual bonus
• healthcare and wellbeing programmes
• pension plan membership
• shares and savings programme

Responsibilities

• Perform analytical characterisation of biotherapeutics using MS and chromatography to generate knowledge for project decisions
• Develop, optimise and troubleshoot analytical methods to identify post-translational modifications and critical quality attributes
• Support early-phase portfolio progression through technology transfer, forced-degradation studies, and analytical strategy delivery
• Plan and deliver high-quality experimental work, analyse complex data, and communicate clear scientific conclusions
• Collaborate across matrix teams in Discovery and CMC Development, contributing technical insight, reports and regulatory documentation
• Maintain high standards of data integrity, scientific rigour, lab safety and effective documentation

Key requirements

• PhD, MSc or equivalent in analytical science, biochemistry, chemistry or related field with application to biopharmaceuticals or therapeutics
• Strong hands-on experience setting up, running and troubleshooting mass spectrometry (Orbitrap and/or Q-TOF)
• Experience of LC-MS or LC-MS/MS and analytical chromatography for protein/therapeutic characterisation
• Knowledge of protein biochemistry and relationship between structure, function and critical quality attributes
• Ability to plan experiments and independently analyse and interpret complex analytical data
• Effective technical communication, organisational and matrix-working skills, commitment to data integrity, documentation and safe lab practice

• effective technical communication
• organisation
• matrix-working
• Mass spectrometry (Orbitrap and/or Q-TOF)
• LC-MS / LC-MS/MS
• Analytical chromatography for protein characterisation

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