Principal Scientist II/Senior Principal Scientist, PK Sciences Clinical Pharmacology Artificial Intelligence (AI) Lead (dual level posting)

Overview

In this role you apply AI-driven strategies to advance clinical pharmacology support for transformative medicines. You will shape AI-enabled solutions across PKS/clinical pharmacology, accelerating deliverables and enabling data-driven decisions. You collaborate across PK science, ADME/BA, and Modeling & Simulation to integrate PK insights into development plans. The position sits within Translational Medicine and offers opportunities to impact bench-to-bedside translation.

Pay / Benefits

• health, life and disability benefits
• 401(k) with company contribution and match
• generous paid time off (vacation, personal days, holidays)
• performance-based incentive
• eligibility for annual equity awards
• comprehensive benefits package

Responsibilities

• Identify and implement high-value AI use cases to improve PKS planning, analyses and decision quality
• Represent PK Sciences in project teams and interactions with stakeholders and regulatory agencies
• Provide pharmacokinetic/pharmacology input to drug candidates across Research, Development and Commercial continuum
• Collaborate with teams to use AI to accelerate understanding of PK/PD relationships and dosing strategies
• Champion AI-enabled preparation of study protocols, reports and regulatory documents (IND/IMPDs, NDA/BLA)
• Foster interdisciplinary collaboration among PKS, ADME/BA, M&S via PK science sub-teams
• Model AI/ML approaches to enable data automation and regulatory document authoring
• Work with clinicians to integrate PKS insights into study design and decision-making

Key requirements

• Ph.D. or Pharm.D. with pharmacokinetics/drug metabolism background
• 0–2 years in drug discovery/development (academic, CRO, biotech or pharma)
• 2+ years in a lead role overseeing ADME/DMPK in clinical development (for Principal Scientist II) or 4+ years for Senior Principal Scientist
• Extensive PK knowledge with PK/PD evaluation and cross-functional team experience
• Experience in global, matrixed project environments
• Strong oral and written communication skills

• strong communication skills
• cross-functional collaboration
• problem-solving mindset
• Artificial intelligence (AI) and machine learning approaches
• PK/PD modeling and simulation (M&S)
• ADME/DMPK expertise

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