Technical Specialist – Single Cell & Spatial Biology

Overview

In this role you enable cutting-edge single-cell spatial omics at King’s Smart Trials Hub, delivering and validating complex workflows across academic and industry projects. You will work within a multidisciplinary team to optimise protocols, manage data quality, and troubleshoot technical challenges, helping to expand the facility’s capabilities. The position offers hands-on work with leading technologies and a clear impact on high-resolution disease biology and personalised therapies.

Responsibilities

• Deliver and optimise single-cell spatial omics workflows (RNA/protein barcoding, cell sorting, NGS, transcriptome analysis)
• Provide expert guidance on experimental design and emerging methodologies
• Maintain and troubleshoot equipment and workflows to ensure data integrity
• Acquire and QC high-quality, reproducible datasets across diverse sample types
• Contribute to method development and continuous expansion of facility capabilities
• Collaborate with multidisciplinary teams and communicate complex scientific information effectively
• Record-keeping and attention to detail to support robust research outputs

Key requirements

• PhD in relevant subject area or equivalent research experience
• Hands-on experience with spatial transcriptomics and/or tissue profiling platforms (Chromium, Visium, Xenium)
• Experience in data analysis and QC of single-cell/spatial transcriptomics data
• Proven ability to develop and optimise workflows for robust, reproducible data
• Experience operating, maintaining, and troubleshooting laboratory equipment
• Strong collaboration skills and ability to communicate with diverse stakeholders
• Excellent written and verbal communication for reports, publications, and presentations
• Ability to work independently, prioritise, and manage multiple projects to deadlines

• Excellent communication and collaboration
• Attention to detail
• Problem-solving mindset
• Spatial transcriptomics and tissue profiling techniques
• NGS data generation and analysis
• Method development and workflow optimisation

…